Archive for October, 2008
Could Chinese Herb Be a Natural Viagra? (HealthDay)
Italian researchers report that laboratory studies show that the compound has the potential to treat erectile dysfunction, and possibly with fewer side effects than its pharmaceutical cousin.
"No in-vivo studies in an animal model have been performed at this regard, so a lot of work must be done. We would like to test in vivo [with animals] the molecule to understand if it really works in humans," said study lead author Mario Dell'Agli, of the University of Milan's laboratory of pharmacognosy. "At this stage of the research, we cannot say if the molecule we have synthesized possesses less side effects by respect to Viagra. However, this derivative seems to have being in vitro [in lab tests] more selective than Viagra, because it targets [an enzyme involved in blood flow to the penis] more precisely."
The study was expected to be published in the Oct. 24 issue of the Journal of Natural Products, a publication of the American Chemical Society.
Viagra (sildenafil) is one of several prescription medications available and widely prescribed for erectile dysfunction, a condition that affects an estimated 18 million men in the United States. Viagra and other drugs like it can cause side effects such as headache, stomach problems and visual disturbances.
Horny goat weed, hailing primarily from southern China, has a long history as an aphrodisiac.
As part of a new screening program to find natural alternatives to Viagra, the study authors analyzed a number of herbal extracts longing used for male impotence, including Ferula hermonis or Lebanese Viagra; Cinnamomum cassia or Chinese cinnamon; as well as Epimedium brevicornum aka horny goat weed. All three extracts are reputed to improve sexual performance.
The main in action component of both select was tested against an enzyme known as phosphodiesterase-5A1 (PDE5A1), which regulates blood supply to the penis. Inhibition of this enzyme results in more blood flow to the penis extender deluxe, resulting in an erection.
Icariin, the active ingredient of horny goat weed, inhibited PDE5A1 to a greater degree than the other compounds tested.
"The novelty of this work is the new molecule we have synthesized by icariin," Dell'Agli reported. "It is derived by chemical modifications of the structure of icariin, which is the active ingredient purified from E. brevicornum (horny goat weed). The mechanism by that the molecule we have found might work in humans is the inhibition of phosphodiesterase 5 (PDE 5) in the corpus cavernosum [erectile tissue in the penis], which is the mechanism by which Viagra works. This is an in vitro study. It can be considered a pre-clinical study."
More information
The National Institutes of Health has more on erectile dysfunction.
1 commentEconomy is overriding issue in governors’ races (AP)
Then came the catastrophe on Wall Street. things being so the economy has become the overriding issue that is tightening governors races over the nation.
“It’s going to exist the No. 1 judgment someone keeps their job or loses it,” said Del Ali, who has conducted polls in sundry governors’ races.
Eleven states elect governors this fall, offering Republicans a chance to reduce the Democrats’ current 28-22 majority of governors’ seats.
And this year is only a prelude to 2010, when three of each five states will elect a governor. The winners of those races will have a crucial edge when it comes time to redraw electoral maps based on the 2010 census.
Earlier in the year, gubernatorial candidates talked about training and health care, along with the economy.
Then came soaring elastic fluid prices, a drumbeat of negative news about state budgets and Wall Street’s unprecedented meltdown. The faltering economy now trumps other topics in several closely watched governors’ races, some of which have grow unexpectedly close.
The financial meltdown “puts an exclamation point on the challenges we’re facing and each express is facing now,” said Vermont Gov. Jim Douglas, a Republican seeking his fourth two-year term in office.
Some states are already reporting problems accessing credit markets for short-term borrowing. The equal in number of states with deficits is increasing. Tax revenue is flat or falling, and many states’ unemployment compensation funds are dangerously low.
In Missouri, the economy was the top issue in recent polls that showed slight gains for Hulshof’s opponent, Democratic Attorney General Jay Nixon.
The race is important enough that President Bush held a fundraiser for Hulshof earlier this month. That led to a swift retort from Nixon linking his opponent to the “failed economic policies of President Bush.”
At a Thursday altercation, Hulshof tried to link Nixon to the state’s past economic troubles: “There was no hand-wringing by means of the attorney general when the previous Democratic governor actually presided over the narrate’s economy.”
In Indiana, Republican Gov. Mitch Daniels leads Democrat Jill Long Thompson in fundraising and spending. But Long Thompson is running even or just slightly behind in recent polls while she hammers Daniels by the claim that the state’s economy is in trouble.
She rushes to remind people that Daniels was Bush’s budget director.
“In Indiana, people know he’s accountable for the largest deficit in the history of the world,” Long Thompson said.
Jobs were up in August in Indiana, but the state’s unemployment rate also rose. The state lost 17,600 jobs in July.
“There’s no way to deny some of the national problems are impacting Indiana, but the governor’s hegemony has certainly put Indiana in a much better position than our neighboring states,” said Daniels’ spokesman Cam Savage.
In North Carolina, a state with a history of electing Democratic governors, the Republican Governors Association is running ads bashing Democratic Lt. Gov. Beverly Perdue over the economy. She’s responded with a spot promoting her work providing jobs.
Republican Pat McCrory, the mayor of Charlotte, says education was the top issue in the past. Now the economy and jobs, along with energy prices, are “definitely attached the minds of almost every area I go,” he said.
Most polls inform a close race.
In Washington, GOP challenger Dino Rossi is criticizing Gov. Christine Gregoire as the state’s projected budget deficit balloons to as much as $3.2 billion. The two are locked in a rematch of their razor-thin 2004 race, which Gregoire won by 133 votes after three recounts and a lawsuit.
The economy was a top issue at sum of two units debates this month, and both are scrambling to take advantage of the crisis.
“In the past four years of Gregoire’s administration, she has left us through piles of debt, higher taxes and rising unemployment,” Rossi said.
Responds Gregoire: “I saw this national economic crisis brewing and fought for the Rainy Day Fund and a budget surplus.”
In Vermont, the economy was a top issue from the beginning. Fear of record heating oil prices was a growing concern for the state, known for its long, cold winters.
Last year, Gov. Douglas used estimates by investment bank Lehman Brothers to propose leasing the category lottery to a private entity for a one-time payment of about $50 million.
Lawmakers were cool to the idea, and at this time Lehman Brothers has filed for insolvency, a fact Douglas’ opponent, outgoing Democratic House Speaker Gaye Symington, is quick to point out.
The come: The case Symington had been making about the parade’s household troubles just got a whole fortune easier to sell.
“Vermonters are making the connection that this guy basically has had that sort of ‘trust corporations, trust Wall Street mentality,” said Symington spokesman Michael Carrese.
Douglas brushes off criticism of his economic plan, arguing that the economy moves in cycles and he’s the best person to take advantage of a recovery when it begins.
“My long experience and ability to provide the leadership necessary to get through a tough time makes it all the more important that I stay on the job,” Douglas said.
The most recent poll last month had Douglas with 48 percent of the vote and Symington with 33 percent. Independent Anthony Pollina had 7 percent, and 12 percent were undecided.
Other states electing governors in races not expected to be as close are: Delaware, New Hampshire, Montana, North Dakota, Utah and West Virginia.
3 commentsHPV infection rates similar in men and women (Reuters)
HPV has long been known as a cause of genital warts, but in recent years most reports have focused on its association with cervical cancer. In 2006, an HPV vaccine (Gardasil) designed to prevent cervical cancer was approved for use and a report released yesterday indicates that roughly one quarter of adolescent girls in the U.S. were vaccinated in 2007.
Because male-to-female transmittal of HPV influences the risk of cancer in women, Dr. Anna R. Giuliano of the H. Lee Moffitt Cancer Center and Research Institute in Tampa, Florida, and colleagues and sought out more information on the matter.
The team conducted a forward-looking study of 290 men from southern Arizona, ages 18-44 years, who were recruited by a variety of means including college posters, encounters at health clinics, and radio and newspaper advertisements.
The participants were examined at the start of the study and every 6 months thereafter. On average, the subjects were followed for 15.5 months.
Upon entering the study, 30 percent of men were infected with HPV. The 12-month rate of new infection was 29.2 percent.
Over the entire study period, roughly half of men were infected with HPV and nearly a third of the HPV types found are known to cause cancer. About 75 percent of the infections cleared within a year of detection.
The HPV vaccine is currently being tested internationally in men.
"Should we show that HPV prevention vaccines…are effective in men we can potentially reduce a proportion of infections acquired by men," which in winding could reduce the risk in their sexual partners, Giuliano concluded.
SOURCE: Journal of Infectious Diseases, September 15, 2008.
No commentsMan’s ‘Viva Viagra’ missile misfires in NYC court (AP)
A federal judge ruled Wednesday that Arye Sachs’ antics infringe on a trademark held by Pfizer Inc.
Sachs was ordered to stop displaying anything with viagra logos.
He towed the 25-foot rocket last month to various spots in Manhattan, including Pfizer’s headquarters.
His plan was to invoke Viagra while distributing politically themed condoms. The judge worried persons would mistake the missile for a Pfizer-approved ad.
Sachs’ phone rang unanswered Wednesday, and lawyers for Pfizer didn’t return phone calls.
2 commentsNYC man sued over 25-foot Viagra rocket (AP)
An attorney for viagra-maker Pfizer Inc. says that the man’s use of the company’s logo could disarrange consumers into thinking the rocket was an actual trumpeting for the drug used to treat male impotence.
But 48-year-old Arye Sachs of West Babylon says no one would be deterred from buying the blue pills on this account that of he what he did. He says he knows on this account that he’s a “customer.”
Sachs hauled the missile adhering a trailer hitched to his car through Manhattan, where he parked it in front of the Trump Tower forward Sept. 8. He also drove it past Pfizer’s headquarters.
___
Information from: New York Post, http://www.nypost.com
No commentsHorny Goat Weed may offer Viagra alternative (Reuters)
The herb has all along held a fame as a natural aphrodisiac. The lab experiments, which did not look at whether the plant actually increases appetency, could lead to new drugs to help men get erections, said Mario Dell'Agli, a researcher at the University of Milan, who led the study.
"This could be the natural viagra," he said in a telephone interview. "The novelty is that we have synthesised a new molecule that one day may be able to replace Viagra."
Erectile dysfunction is a common condition worldwide, and drugs like Pfizer Inc's But the medicines, which inhibit every enzyme called phosphodiesterase type 5 that restricts blood flow around the body, including to the penis extender deluxe, can have side effects ranging from headaches, upset stomach and visual problems including blindness.
The Italian team looked for alternatives through studying a number of plants reputed to boost sexual performance.
After homing in on corneous horny goat weed, the researchers modified a compound in the plant called icariin and found it blocked the erection-inhibiting enzyme as well as Viagra did.
Because the compound targets the enzyme more precisely, it may have fewer side effects than Viagra, known generically as sildenafil, Dell'Agli said.
Further tests in animals and humans are needed but the extract from the herb represents a potential new erectile dysfunction manipulation with fewer side effects, Dell'Agli said.
"The compound icariin is present in the horny goat weed in large amounts and its activity against (the enzyme) is lower compared to Viagra," he said. "But the new indivisible particle we synthesized from icariin is as good as Viagra against (the enzyme)."
(Reporting by Michael Kahn; Editing by Maggie Fox and Elizabeth Piper)
No comments